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Senin, 18 Maret 2019

Ebook Basic Principles of Drug Discovery and Development

Ebook Basic Principles of Drug Discovery and Development

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Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development


Basic Principles of Drug Discovery and Development


Ebook Basic Principles of Drug Discovery and Development

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Basic Principles of Drug Discovery and Development

From the Back Cover

Basic Principles of Drug Discovery and Development clearly explains the fundamental principles of the drug discovery and development process from a multidisciplinary approach. This text is ideal for readers interested in a career in the pharmaceuticals industry or nonscientists seeking an understanding of how drugs reach the marketplace. This book explains the multifaceted process of identifying new therapeutic agents in the modern era and describes the input required from a host of experts such as medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, and clinicians. Given the wide range of disciplines and techniques required for cutting-edge drug discovery research, it is important that scientists have a mastery of not only their own field, but also an understanding of their collaborators’ fields. In order to provide readers with an understanding of a wide range of fields, this book describes enabling technologies for a variety of disciplines that are critical to the process. High throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, translational medicine, and many other scientific methods that have become critical to the successful development of marketable therapeutics are described. Beginning with an historical overview of drug discovery, this book educates the reader about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Key features Provides an introduction to the drug discovery process from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyWritten for anyone looking to learn about or thinking of entering the pharmaceutical industrySimply and succinctly presents how the pharmaceutical industry works

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About the Author

As an industrial medicinal chemist, Dr. Blass has experience with major pharmaceutical organizations (Wyeth, Procter & Gamble Pharmaceuticals) and small biotech operations (Fox Chase Chemical Diversity Center), which provided him with a wealth of expertise in the art of drug discovery and development (including a wide range of disease states and biological targets). His position with Temple University’s School of Pharmacy and the Moulder Center for Drug Discovery has provided him with essential experience as an educator and academic scientist. These experiences, as well as his training and expertise as a registered US patent agent, have provided him with the tools and skills necessary to bridge the gap between industrial drug discovery and academic research.

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Product details

Paperback: 580 pages

Publisher: Academic Press; 1 edition (May 11, 2015)

Language: English

ISBN-10: 012411508X

ISBN-13: 978-0124115088

Product Dimensions:

6 x 1.3 x 8.8 inches

Shipping Weight: 2.1 pounds (View shipping rates and policies)

Average Customer Review:

4.5 out of 5 stars

4 customer reviews

Amazon Best Sellers Rank:

#353,566 in Books (See Top 100 in Books)

Very comprehensive

great book for a drug discovery class

Good, readable introduction to the topic. The index would be more useful if it had a couple more entries, though. Haven't finished reading it yet, but no other complaints so far.

Very nice book!

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Jumat, 08 Maret 2019

Download Ebook Montreal and Quebec City Colourguide (Colourguide Travel)

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Montreal and Quebec City Colourguide (Colourguide Travel)

Montreal and Quebec City Colourguide (Colourguide Travel)


Montreal and Quebec City Colourguide (Colourguide Travel)


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Montreal and Quebec City Colourguide (Colourguide Travel)

Review

"These are books to keep for reference or to give as presents... they're readable, informative and beautiful. I hope they eventually do one for each province and territory." (Elizabeth Cran Guardian Patriot)"...the strength of these guides lies in the colour photography and heavily detailed copy in the Top Attractions, Neighbourhoods, and History sections." (Tralee Pearce The Globe and Mail)

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About the Author

Melanie Grondin is a Montreal writer, editor and translator.

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Product details

Series: Colourguide Travel

Paperback: 216 pages

Publisher: Formac Publishing Ltd.; fifth edition edition (April 14, 2010)

Language: English

ISBN-10: 0887809014

ISBN-13: 978-0887809019

Product Dimensions:

4.5 x 0.5 x 8.5 inches

Shipping Weight: 10.6 ounces (View shipping rates and policies)

Average Customer Review:

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Amazon Best Sellers Rank:

#4,065,361 in Books (See Top 100 in Books)

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Minggu, 03 Maret 2019

PDF Ebook Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young

PDF Ebook Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young

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Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young

Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young


Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young


PDF Ebook Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young

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Love, Honor, and Virtue: Gaining or Regaining a Biblical Attitude Toward Sexuality, by Hal Young Melanie Young

About the Author

Hal & Melanie Young are the award-winning authors of Raising Real Men and My Beloved and My Friend: How to Be Married to Your Best Friend Without Changing Spouses. They are publishers, writers, bloggers, and popular conference speakers internationally, known for their Christ-centered focus and practical, real-life stories. They are the parents of six real boys (four grown!) and two real girls and live in noisy, messy happiness in small town America.

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Product details

Paperback: 104 pages

Publisher: Great Waters Press (February 1, 2017)

Language: English

ISBN-10: 1938554124

ISBN-13: 978-1938554124

Product Dimensions:

6 x 0.2 x 9 inches

Shipping Weight: 5.9 ounces (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

7 customer reviews

Amazon Best Sellers Rank:

#105,370 in Books (See Top 100 in Books)

Pertinent information and helpful ideas for men who want to remain pure in a world that is straying from Biblical principles.

Lots of good information and encouragement as we go through this next step in parenting. My son wasn’t quite ready for all the information presented in this book. But when he is it will be a good resource.

A great book that gives all the important details without being too graphic. I highly recommend it.

know this isn't new, but I wish I had this book when my children were younger. The Youngs cover every topic you need to deal with in thisthe world where it seems everything and everyone is trying to steal your children.Even if you add your own twist to their ideas so that it suits your family better, you will have a good base to build from.It would also work to read this with your child - after you've read it yourself.No Longer Little: Parenting Tweens with Grace and Hope

As a mom with righteous indignation over the pornography culture in which we live, there may not be a more important book for young men. It's worth the fight and this book is a weapon in the battle.

Today's online environment is just plain scary. Even with app blockers and filtering software on their devices, kids can get into stuff - not to mention, at some point they're going to have to navigate the web on their own as adults. This is an excellent book that clearly and straightforwardly addresses how and why to avoid internet pitfalls. It's written directly to young people without being preachy. I can't recommend this book enough.

Excellent book for pre-teens & teens to read with parents. Yet another great book from Hal and Melanie (Young Raising Real Men). We have learned so much from their literature and enjoyed hearing them speak in person. This book should be mandatory for all sex education classes in the USA! We would have many less broken hearted pre-teens and teens if parents and grandparents had read this book and passed it on to their children/grandchildren.

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Jumat, 22 Februari 2019

Ebook Download Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman

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Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman

Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman


Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman


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Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman

Review

"Birds of the Hom of Africa is another excellent publication in the Princeton Field Guides series."---Frederic Brock, Wildlife Activist"Birds of the Horn of Africa is a welcome addition to the literature on the birds of Africa. . . . [I]t is an outstanding work."―Emil K. Urban, Augusta State University"This eagerly awaited field guide is the first ever to cover the stunning birds of an outstanding region. . . . With its unrivalled, truly authoritative coverage, Birds of the Horn of Africa is indispensable for birders and ornithologists alike."―C. Hilary Fry, University of Aberdeen"This is one of the best field guides in the world. The writing is of a very high standard, and I am impressed by the overall quality of the plates and attention paid to local subspecies. Birds of the Horn of Africa is the premier field guide to the region."―Keith N. Barnes, editor of The Eskom Red Data Book of Birds of South Africa, Lesotho, and Swaziland

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From the Back Cover

"Birds of the Horn of Africa is a welcome addition to the literature on the birds of Africa. . . . [I]t is an outstanding work."--Emil K. Urban, Augusta State University"This eagerly awaited field guide is the first ever to cover the stunning birds of an outstanding region. . . . With its unrivalled, truly authoritative coverage,Birds of the Horn of Africa is indispensable for birders and ornithologists alike."--C. Hilary Fry, University of Aberdeen"This is one of the best field guides in the world. The writing is of a very high standard, and I am impressed by the overall quality of the plates and attention paid to local subspecies.Birds of the Horn of Africa is the premier field guide to the region."--Keith N. Barnes, editor ofThe Eskom Red Data Book of Birds of South Africa, Lesotho, and Swaziland

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Product details

Series: Princeton Field Guides (Book 51)

Paperback: 488 pages

Publisher: Princeton University Press; First Edition edition (July 26, 2009)

Language: English

ISBN-10: 0691143455

ISBN-13: 978-0691143453

Product Dimensions:

5.8 x 1.2 x 8.8 inches

Shipping Weight: 15.2 ounces

Average Customer Review:

4.7 out of 5 stars

19 customer reviews

Amazon Best Sellers Rank:

#1,992,208 in Books (See Top 100 in Books)

Basics: 2009, softcover, 496pp, field/identification guide, 213 color plates of all 1,000+ species in the region; range mapsThis is another top quality book produced by the authors for the eastern region of Africa. Upon opening this book, you'll recognize many of the plates from their earlier work, "Field Guide to the Birds of East Africa" (see #6 below). You'll also see many new plates along with modifications of prior ones.The artistry is very good, easily making this book equal to or better than any other field guide on African birds. The 213 color plates illustrate all 1,000+ species found in the four "Horn" countries of Eritrea, Ethiopia, Djibouti and Somalia (plus the island of Socotra, which belongs to Yemen). Nearly every bird is shown with multiple (2-5) drawings that display excellent detail. The Yellow Wagtail has 13 different illustrations that compare the wide variation of this species. The plates do a great job at showing variations between genders, ages, and subspecies. I especially appreciated the extra effort that went into separating out the many subspecies. Additional focus seems to have been given to in-flight poses for many of the non-passerines.A brief paragraph is given for each bird across from its illustration. Although the amount of text may seem light, the information is very informative, to the point, and precise. About 80% of the information is on identification. A couple more lines are dedicated to habitat, distribution notes, and voice. You may want to take note of the font size, which is small and thin; consequently, you might want to have your reading glasses handy.The range maps - one for each bird - shows the resident, breeding, and non-breeding ranges in three different colors. These maps reflect the bird's range within only the four countries and artificially stop at the political borders. The maps show very good detail; however, this is sometimes difficult to make out due to the shaded highland regions in the background and to the rather faint gray boundaries that separate the countries. Ranges of birds with a very restricted distribution (e.g., Sidamo Lark, Ash's Lark, Djibouti Francolin, Black-backed Cisticola) can be difficult to see with just a small dot representing the range. Inserting an arrow would have been helpful. Making a more prominent note of the 70+ endemics would also have been appreciated, versus simply burying the word "endemic" within the text.In case you're wondering if you would need this book over the authors' prior book for East Africa, the answer is "Yes, if you are visiting any of these four countries." Twenty percent of the birds found in the Horn are not in the other book. Also, when there is overlap of the species between the two regions, the authors' have modified the plates to reflect the plumages of the local subspecies.This is a superb guide that will be essential for birding in these countries. Being the only complete book for this region makes it even more indispensible.1) Birds of Ethiopia and Eritrea by Atkins/Ash2) Ethiopia's Endemic Birds by Urban3) A Guide to Endemic Birds of Ethiopia and Eritrea by Pol4) Ethiopia: In Search of Endemic Birds by Francis5) Birds of Somalia by Ash6) Field Guide to the Birds of East Africa by Stevenson7) Birds of Africa South of the Sahara by Sinclair/Ryan8) Birds of Kenya and Northern Tanzania by Zimmerman9) A Checklist of the Birds of Ethiopia by Urban(written by Soleglad at Avian Review or Avian Books, May 2009)

we used this book during our 27 day journey through Ethiopia. Its excellent and we would have been lost without it. The index is clear the images good and the descriptions of the birds very helpful - they highlight what you need to concentrate on.

Being stationed in Djibouti I was amazed of all the birds that flew through the airfield. I tried to look them up but to no avail, I couldn't find a book that would help. Last week Mat Klope came by to perform a wildlife survey of the birds and animals in Djibouti and in his hand was this book. I was amazed that someone even took the time to log the regions where the birds live. I've worked in the Aviation industry since high school and repaired countless aircraft after a "bird strike." Learning more about the birds that live in the regions where I work

An excellent book we look forward to using when we visit these countries in January 2020Similar to one we used when we visited Uganda & Rwanda last October : color plates & descriptions & maps are outstanding

I've been using this book while working and traveling in the Horn of Africa. It has been very useful ... I really like the layout--the pictures are excellent representations of the species (and as one reviewer noted, subspecies). The flight profiles and range maps have been key to my identifying some birds--the hardest birds to identify I find are the plain ones and this book does a very good job of describing and showing the subtle variations required for positive identification. My copy is now dog-eared, coffee-stained, and marked up ... After 3 months, the binding is coming loose somewhat but the pages are still stitched in pretty well. It's been stuffed in backpacks, thrown on hot dashes, tossed around in a dive bag on the beach--so it's holding up very well all things considered!If you are coming this way and you like birds, it's the book for you! Highly recommend.

I was really excited to order this book and the color plates are terrific. However, the range maps are so minute that they're a joke. They are pretty well impossible to read, even with a magnifying glass. I realize that the only alternative is to have the range maps on a separate page, but that would be preferable to not being able to read them

While heavy, it is comprehensive and easy to use. Excellent index and plates. Fellow birders carried smaller Birds of Eastern Africa and kept asking to see my Redman guide. Local guides also used Birds of the Horn...I recommend Redman's book strongly.

This is another excellent bird guide by the authors. On a recent trip to Ethiopia, I found this book to be an indispensable companion. The drawings are outstanding as is the text on each bird. The range maps and in particular the elevation guides were very helpful in this geographically variable country. The details of this guide are well covered in previous reviews and this book would be a welcome addition to the library of those who love to travel in Africa. I left this guide with our local semi-bird guide to encourage his growth in birding. He was both emotional and appreciative to receive this book. I bought a new one on my arrival home. Ted Peterson Lynnwood WA USA

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Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman PDF

Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman PDF

Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman PDF
Birds of the Horn of Africa: Ethiopia, Eritrea, Djibouti, Somalia, and Socotra (Princeton Field Guides), by Nigel Redman PDF

Senin, 11 Februari 2019

Download PDF The Chopper: The Real Story

Download PDF The Chopper: The Real Story

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The Chopper: The Real Story

The Chopper: The Real Story


The Chopper: The Real Story


Download PDF The Chopper: The Real Story

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The Chopper: The Real Story

Product details

Hardcover: 256 pages

Publisher: Gestalten (November 10, 2014)

Language: English

ISBN-10: 9783899555240

ISBN-13: 978-3899555240

ASIN: 3899555244

Product Dimensions:

10 x 1.2 x 13.2 inches

Shipping Weight: 4.7 pounds (View shipping rates and policies)

Average Customer Review:

4.6 out of 5 stars

17 customer reviews

Amazon Best Sellers Rank:

#944,912 in Books (See Top 100 in Books)

This long-overdue book is a new and refreshing approach to the subject of chopper motorcycles. It's the first book I've yet seen that tells the fascinating story of choppers based on extensive new and original research by its author, which includes personal interviews with hitherto little known yet important chopper old timers. He digs past the hearsay and the myths, and he avoids repeating any chopper cliches without first verifying that they are truly based on fact. Other books on this subject tend to be 90% glossy photos and 10% of text that is simply a re-hash of the same old re-cycled myths and legends. Paul D'Orleans here shows that the verifiable truth is at times quite different from the popular stereotypes of choppers and chopper people, yet the truth is no less fascinating than the distortions of legend. He uncovers some genuine new chopper heroes who have remained in almost complete obscurity, until now. The major innovators and the key technical developmental stages of choppers (e.g. the origin of an extender springer that actually handles) are revealed here for the first time. Paul gives the subject of chopper motorcycles the seriousness that it deserves as a valid field of motorcycle engineering, then sets it within its true context as a folk art form that is one of America's most significant cultural contributions to humankind during the 20th century. As a connoisseur both of fine motorcycles and of fine art, Paul D'Orleans is the perfect person to have produced this book. Buy it. You won't regret it.

Vivid pix/well made

First let me say the cover is brilliant, but then you open the book.It is very well research and offers an unbiased account of the evolution of the chopper.The author does a good job sorting through the myths that have grown up around the "Biker" culture laying out good time line of the development of the custom motorcycle.There are incites and stories that I had never heard before and as a historical research document it is worth the money. If there ever was an example of why a great editor earns his money this is it, as this book is badly in need one. It appears to be a collection of blog post put together in a some what chronological order. Information is repeated, not always the same, making it read in a hit and miss manner. References to photos that are pages away or not in the book abound. Type face selection is really strange and the layout of the book is worse than any high school yearbook I have ever seen.The research and the photos make it worth the price,It is such a shame that so little thought went into the production of the book, it ends just being a collection of photos and facts, while lacking any soul.

This is one book that needs to be read as well as prominently displayed with your motorcycle memorabilia.

Good book, big pictures, you want it, just buy it.

Excellent book...well researched and well presented.

I would have gave the book a higher rating except for the fact that I feel the content and paper quality is not deserving of the high selling price. It's a decent book on the subject of Choppers, providing many pics and some history, but the book should be priced at about $25.00, max.

Great gift idea. Heavy duty cover and pages.

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Senin, 28 Januari 2019

Download PDF Master The Special Agent Exam

Download PDF Master The Special Agent Exam

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Master The Special Agent Exam

Master The Special Agent Exam


Master The Special Agent Exam


Download PDF Master The Special Agent Exam

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Master The Special Agent Exam

Product details

Series: Master the Special Agent Exam

Paperback: 240 pages

Publisher: Peterson's; 12 edition (November 2, 2009)

Language: English

ISBN-10: 0768927951

ISBN-13: 978-0768927955

Product Dimensions:

8.5 x 0.5 x 11 inches

Shipping Weight: 1.1 pounds (View shipping rates and policies)

Average Customer Review:

3.3 out of 5 stars

50 customer reviews

Amazon Best Sellers Rank:

#99,812 in Books (See Top 100 in Books)

Lots of spelling errors, missing words. I could get over that, but on the math instructional portion, there are incorrect explanations and solutions, making using this to brush up or learn the math counterproductive. Seemed hastily put together, and it's from 2009.

I bought this book to help prep for the ATF exam and I must say the books math portion is a lot more intense then the actual test. This book was made in 2009 when the ATF still utilized the treasury exam, however the test now is specifically toward ATF. I will say if you can pass the practice exams in this book you will have no problem with the extremely short ATF exam. This is definitely a "practice harder than you play" book.

Good book but it didn’t help me for the DEA Exam.

This book has typos and incorrect solutions to the math problems. Do not rely on the provided answers at all.

This is not even close in relation to the actual FBI SA exam. Not pleased with the money and time spent using this book and it doesn't even reflect the SA test.

Great product

must get if you are applying to federal, state or local city jobs, they all share same concept of questions that this book covers

This book was harder than the SA test. It covers pretty much anything you might come across on the test.

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Senin, 10 Desember 2018

Ebook , by Justin Patrick

Ebook , by Justin Patrick

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, by Justin Patrick

, by Justin Patrick


, by Justin Patrick


Ebook , by Justin Patrick

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, by Justin Patrick

Product details

File Size: 1497 KB

Print Length: 34 pages

Simultaneous Device Usage: Unlimited

Publication Date: July 18, 2014

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B00LY6CII6

Text-to-Speech:

Enabled

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X-Ray:

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Word Wise: Enabled

Lending: Not Enabled

Enhanced Typesetting:

Enabled

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Amazon Best Sellers Rank:

#255,800 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

It doesn't appear that English is Mr. Patrick's first language. I have no problem with that but if you're going to write a book in a language that is not your native tongue, have somebody proofread it first! I know it was only a buck to buy but it was so difficult to follow it made me wish I hadn't bought it.

Very poorly proof-read! Somebody should tell the author to do a spellcheck on Word or whatever processor he uses. Very distracting. As to the meat of the book, I was not very impressed by his level of expertise in this field. I think that I know more about it than he does, and I am a virtual novice. There is very little of substance; I think he wrote the book after reading a couple of other, better books on the subject. Not enough meat on this bone...

i must be honest..i a shocked at the raft of positive reviews for this book. to be honest..i am shocked it is called a 'book'. there are pamphlets with more information than this, and would take longer to read. this book should at most take someone 6 minutes cover to cover. there's bugger all information in it.

I wish the author had spent more time with the writing, and editing, of this volume. A bit too simple.

Absolutely empty. I hope my money is used for agood cause.

No substance to this book! Didn't go into any detail. Simply a brochure. You can learn way more on your own.

This short guide is packed full of good information to start your offshore banking journey. Many myths are dispelled and facts are provided. In this day and age of uncertain economies and governments, it's good to educate yourself on the possibilities of where you can safely invest your money. Apparently, the errors mentioned in another review have been corrected. I may have spotted a typo or two but nothing bad enough to take away a star from this five star guide.

A very simple guide to learn from and a must read!

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